Setien was named Barcelona coach late on Monday, tasked with the job of restoring the club's iconic passing style, but the appointment represents a huge gamble for the Catalans given the 61-year-old's lack of success at the highest level.
Real Madrid failed in their attempt to sign France striker Kylian Mbappe from Paris Saint Germain on the final day of the transfer window as Cristiano Ronaldo completed his move from Juventus to Manchester United.
Karim Benzema netted a second-half hat-trick as Real Madrid got back to winning ways with a 3-0 victory over Athletic Bilbao in La Liga on Sunday.
La Liga leaders Barcelona hit two goals in the final three minutes to earn a 3-2 win at Rayo Vallecano
Barcelona's Sergi Roberto and Robert Lewandowski struck just before halftime to give the league leaders a 2-0 home win over lowly Cadiz on Sunday in their pursuit of a 27th Spanish title.
Barcelona were held 1-1 at home by Napoli in the first leg of their Europa League knockout stage playoff
A summary of Saturday's action in La Liga, Serie A and Bundesliga.
IMAGES from the football matches played across Europe on Sunday.
Arsenal had scored 10 goals in two matches against BATE Borisov in the same competition in 2017 but never looked like being as prolific in the freezing temperatures of Belarus.
The clinical Argentine Messi now has 11 goals in his last five games in all competitions and with record signing Ousmane Dembele injured and Luis Suarez rested, he put on a sensational show at Camp Nou to extend Barcelona's La Liga lead.
Images from the football matches played across Europe on Sunday
Rashford scores a brace as Man United fight back to beat Omonia
A total of 18 people, including three soccer players, are to stand trial for match-fixing, a judge in Pamplona ruled on Thursday.
With Crystal Palace dangerously close to being relegated, manager Patrick Vieira was sacked after 20 months in charge.
Images from football matches played in La Liga and Serie A in Spain and Italy on Wednesday.
Cristiano Ronald headed his 300th goal for Real Madrid in a laboured 2-0 La Liga victory at neighbours Rayo Vallecano on Wednesday that kept the gap on leaders Barcelona down to four points.
Veteran actor Junior Mehmood, who was battling with stage four cancer passed away in Mumbai on Friday.
Barcelona, reduced to 10-man in the last half-an-hour, clinched a narrow win over Valencia in their La Liga match on Sunday.
The draw means second-placed Atletico Madrid could close the 12-point gap with Barcelona, who are on 74 points, if they beat Celta Vigo later on Saturday.
The rest of Barcelona's squad will have to do "a little bit more" to make up for the absence of five-times World Player of the Year Lionel Messi for the next three weeks, according to captain Andres Iniesta. The Argentina forward faces a spell on the sidelines after sustaining a groin injury in Wednesday's 1-1 La Liga draw with Atletico Madrid. "There's no question we are stronger with Messi," Iniesta told Cadena Cope radio ahead of Saturday's match at Sporting Gijon. "When these things happen we all have to give a little bit more.
Images from Sunday's action in La Liga and Ligue 1.
Fresh from propelling Barcelona to their fifth trophy of 2015, their prolific strikes are now seeking to break the Spanish record of goals in a calendar year when they play Real Betis on Wednesday.
News of all that's transpired on and off the football field.
Jaume Costa atoned for giving away a first-half penalty when his strike five minutes from time rescued Villarreal a 1-1 draw against Eibar that put them fourth in La Liga on Sunday.
Spanish soccer clubs Villarreal and Getafe have denied any wrongdoing after national media reported on Friday that police are investigating possible match-fixing in a 2-2 draw between the two clubs in La Liga last year. Newspaper El Pais reported that the match was being looked at as part of Operation Oikos, which was launched last year and led to 11 people being arrested on suspicion of forming a match-fixing group to profit from betting on games.
La Liga has taken legal action against 10 people who allegedly threatened Ukraine international Roman Zozulya following his move to Rayo Vallecano last week, the Spanish league said in a statement on Thursday.
Images from Sunday's action in the Premier League.
Atletico Madrid stayed firmly on course for a surprise La Liga title triumph when Raul Garcia's header secured a 1-0 win for the leaders at home to seventh-placed Villarreal on Saturday.
Ansu Fati is the second-youngest player to represent the Catalan giants in La Liga aged 16 years and 298 days.
Barcelona's inconsistency over the season had cost them the La Liga title, coach Luis Enrique has said.
Barcelona will attempt to give Luis Enrique his 100th victory in his 125th game in charge of the team when they play at Athletic Bilbao in la Liga on Sunday. A former Barca player, the 46-year-old led them to a La Liga, King's Cup and Champions League treble in his first year in charge and the domestic double last season. The Catalans started the campaign with a 5-0 aggregate triumph over Sevilla in the Spanish Super Cup and a 6-2 victory over Real Betis in La Liga.
A dominant yet wasteful Real ravaged their rivals in the first half while spurning a string of clear chances at the Santiago Bernabeu.
Images from Europa League matches played on Thursday.
Barcelona forward Lionel Messi will be out for between six and eight weeks with a hamstring injury, the La Liga leaders said on Monday.
After an almighty push by all parties concerned, Spain's La Liga roars back into action next week after a three-month pause due to the COVID-19 pandemic, with matches taking place every day and with everything to play for. The season resumes on Wednesday in bizarre circumstances with the second half of a Segunda Division match between Rayo Vallecano and Albacete that was abandoned in December due to offensive chanting.
'For me, Nitin Chandrakant Desai will always be associated with masti-mazaak.'
Rangers joined Barca in the last eight despite losing 2-1 at Red Star Belgrade, progressing 3-2 on aggregate.
Villarreal continued their impressive revival after a season in the second division when Jeremy Perbet and Jonathan Pereira struck in a 2-1 win at home to Espanyol in La Liga on Thursday.
Thirteen teams have now qualified for the last 32 including Bayer Leverkusen, FC Zurich and Lazio who had already secured places in the next stage of the competition.
Lionel Messi kept his nerve from the penalty spot to give Barcelona a 1-0 win over Real Sociedad in La Liga on Saturday and return his side to the top of the table.
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